Microneedle-assisted genome editing: A transdermal strategy of targeting NLRP3 by CRISPR-Cas9 for synergistic therapy of inflammatory skin disorders

We report a dissolvable microneedle (MN) patch that can mediate transdermal codelivery of CRISPR-Cas9–based genome-editing agents and glucocorticoids for the effective treatment of inflammatory skin disorders (ISDs). The MN is loaded with polymer-encapsulated Cas9 ribonucleoprotein (RNP) targeting N...

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Detalles Bibliográficos
Autores principales: Wan, Tao, Pan, Qi, Ping, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946375/
https://www.ncbi.nlm.nih.gov/pubmed/33692106
http://dx.doi.org/10.1126/sciadv.abe2888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946375/
https://www.ncbi.nlm.nih.gov/pubmed/33692106
http://dx.doi.org/10.1126/sciadv.abe2888

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