Antagonistic roles for Ataxin-2 structured and disordered domains in RNP condensation

Ataxin-2 (Atx2) is a translational control molecule mutated in spinocerebellar ataxia type II and amyotrophic lateral sclerosis. While intrinsically disordered domains (IDRs) of Atx2 facilitate mRNP condensation into granules, how IDRs work with structured domains to enable positive and negative reg...

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Detalles Bibliográficos
Autores principales: Singh, Amanjot, Hulsmeier, Joern, Kandi, Arvind Reddy, Pothapragada, Sai Shruti, Hillebrand, Jens, Petrauskas, Arnas, Agrawal, Khushboo, RT, Krishnan, Thiagarajan, Devasena, Jayaprakashappa, Deepa, VijayRaghavan, K, Ramaswami, Mani, Bakthavachalu, Baskar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946432/
https://www.ncbi.nlm.nih.gov/pubmed/33689682
http://dx.doi.org/10.7554/eLife.60326

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946432/
https://www.ncbi.nlm.nih.gov/pubmed/33689682
http://dx.doi.org/10.7554/eLife.60326

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