The long noncoding RNA CRYBG3 induces aneuploidy by interfering with spindle assembly checkpoint via direct binding with Bub3

Aneuploidy is a hallmark of genomic instability that leads to tumor initiation, progression, and metastasis. CDC20, Bub1, and Bub3 form the mitosis checkpoint complex (MCC) that binds the anaphase-promoting complex or cyclosome (APC/C), a crucial factor of the spindle assembly checkpoint (SAC), to e...

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Detalles Bibliográficos
Autores principales: Guo, Ziyang, Dai, Yingchu, Hu, Wentao, Zhang, Yongsheng, Cao, Zhifei, Pei, Weiwei, Liu, Ningang, Nie, Jing, Wu, Anqing, Mao, Weidong, Chang, Lei, Li, Bingyan, Pei, Hailong, Hei, Tom K., Zhou, Guangming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946627/
https://www.ncbi.nlm.nih.gov/pubmed/33564066
http://dx.doi.org/10.1038/s41388-020-01601-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946627/
https://www.ncbi.nlm.nih.gov/pubmed/33564066
http://dx.doi.org/10.1038/s41388-020-01601-8

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