Self and microbiota-derived epitopes induce CD4(+) T cell anergy and conversion into CD4(+)Foxp3(+) regulatory cells

The physiological role of T cell anergy induction as a key mechanism supporting self-tolerance remains undefined, and natural antigens that induce anergy are largely unknown. In this report, we used TCR sequencing to show that the recruitment of CD4(+)CD44(+)Foxp3(−)CD73(+)FR4(+) anergic (Tan) cells...

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Detalles Bibliográficos
Autores principales: Kuczma, Michal P., Szurek, Edyta A., Cebula, Anna, Ngo, Vu L., Pietrzak, Maciej, Kraj, Piotr, Denning, Timothy L., Ignatowicz, Leszek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946630/
https://www.ncbi.nlm.nih.gov/pubmed/33139845
http://dx.doi.org/10.1038/s41385-020-00349-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946630/
https://www.ncbi.nlm.nih.gov/pubmed/33139845
http://dx.doi.org/10.1038/s41385-020-00349-4

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