Cargando…

HDAC inhibition potentiates anti-tumor activity of macrophages and enhances anti-PD-L1-mediated tumor suppression

Despite the widespread use of the blockade of immune checkpoints, for a significant number of cancer patients, these therapies have proven ineffective, presumably due to the immunosuppressive nature of the tumor microenvironment (TME). Critical drivers of immune escape in the TME include tumor-assoc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Xiaolei, Su, Xiao, Liu, Rui, Pan, Yongsha, Fang, Jiankai, Cao, Lijuan, Feng, Chao, Shang, Qianwen, Chen, Yongjing, Shao, Changshun, Shi, Yufang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946638/ https://www.ncbi.nlm.nih.gov/pubmed/33564072 http://dx.doi.org/10.1038/s41388-020-01636-x

Ejemplares similares

Harnessing tumor-associated macrophages as aids for cancer immunotherapy
por: Li, Xiaolei, et al.
Publicado: (2019)

Skeletal muscle stem cells confer maturing macrophages anti‐inflammatory properties through insulin‐like growth factor‐2
por: Fang, Jiankai, et al.
Publicado: (2020)

Adipose-derived mesenchymal stromal cells promote corneal wound healing by accelerating the clearance of neutrophils in cornea
por: Shang, Qianwen, et al.
Publicado: (2020)

Inflammatory cytokines-stimulated human muscle stem cells ameliorate ulcerative colitis via the IDO-TSG6 axis
por: Zhang, Shengchao, et al.
Publicado: (2021)

Macrophages inhibit adipogenic differentiation of adipose tissue derived mesenchymal stem/stromal cells by producing pro-inflammatory cytokines
por: Ma, Hui, et al.
Publicado: (2020)

Targeting macrophage anti-tumor activity to suppress melanoma progression
por: Wang, Huafeng, et al.
Publicado: (2017)

IL4I1-catalyzed tryptophan metabolites mediate the anti-inflammatory function of cytokine-primed human muscle stem cells
por: Zuo, Muqiu, et al.
Publicado: (2023)

Selective HDAC6 inhibitors improve anti-PD-1 immune checkpoint blockade therapy by decreasing the anti-inflammatory phenotype of macrophages and down-regulation of immunosuppressive proteins in tumor cells
por: Knox, Tessa, et al.
Publicado: (2019)

Optimized dose selective HDAC inhibitor tucidinostat overcomes anti-PD-L1 antibody resistance in experimental solid tumors
por: Zhang, Pei, et al.
Publicado: (2022)

Roles of tumor-associated macrophages in anti-PD-1/PD-L1 immunotherapy for solid cancers
por: Zhang, Hao, et al.
Publicado: (2023)

Low-dose HDACi potentiates anti-tumor activity of macrophages in immunotherapy
por: Li, Xiaolei, et al.
Publicado: (2021)

Author Correction: Selective HDAC6 inhibitors improve anti-PD-1 immune checkpoint blockade therapy by decreasing the anti-inflammatory phenotype of macrophages and down-regulation of immunosuppressive proteins in tumor cells
por: Knox, Tessa, et al.
Publicado: (2019)

Induction of autophagy does not alter the anti-tumor effects of HDAC inhibitors
por: Newbold, A, et al.
Publicado: (2012)

HDAC inhibitors enhance the anti-tumor effect of immunotherapies in hepatocellular carcinoma
por: Shen, Chen, et al.
Publicado: (2023)

Mesenchymal stromal cells pretreated with pro‐inflammatory cytokines promote skin wound healing through VEGFC‐mediated angiogenesis
por: Zhu, Mengting, et al.
Publicado: (2020)

Population pharmacokinetic models of anti-PD-1 mAbs in patients with multiple tumor types: A systematic review
por: Shang, Jingyuan, et al.
Publicado: (2022)

Anti-Tumor Strategies by Harnessing the Phagocytosis of Macrophages
por: Li, Si-Yuan, et al.
Publicado: (2023)

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory
por: Poggio, Mauro, et al.
Publicado: (2019)

Anti-tumor effects of anti-PD-L1 therapy in an orthotopic bladder tumor model
por: Lyon, Amanda, et al.
Publicado: (2014)

Polyoxazoline‐Based Nanovaccine Synergizes with Tumor‐Associated Macrophage Targeting and Anti‐PD‐1 Immunotherapy against Solid Tumors
por: Matos, Ana I., et al.
Publicado: (2023)

Nitric oxide-dependent immunosuppressive function of thymus-derived mesenchymal stromal/stem cells
por: Su, Xiao, et al.
Publicado: (2023)

Dipeptidyl peptidase 4 inhibitor reduces tumor-associated macrophages and enhances anti-PD-L1-mediated tumor suppression in non-small cell lung cancer
por: Zuo, Bei, et al.
Publicado: (2023)

Platelet PD-L1 suppresses anti-cancer immune cell activity in PD-L1 negative tumors
por: Zaslavsky, Alexander B., et al.
Publicado: (2020)

IFNγ and TNFα synergistically induce apoptosis of mesenchymal stem/stromal cells via the induction of nitric oxide
por: Li, Xiaolei, et al.
Publicado: (2019)

Iron Induces Anti-tumor Activity in Tumor-Associated Macrophages
por: Costa da Silva, Milene, et al.
Publicado: (2017)

HDAC6 selective inhibition of melanoma patient T-cells augments anti-tumor characteristics
por: Laino, Andressa S., et al.
Publicado: (2019)

Local IFNα enhances the anti-tumoral efficacy of systemic anti-PD1 to prevent tumor relapse
por: Guerin, Marion v, et al.
Publicado: (2020)

IGF2R-initiated proton rechanneling dictates an anti-inflammatory property in macrophages
por: Wang, Xuefeng, et al.
Publicado: (2020)

Amplification of spatially isolated adenosine pathway by tumor–macrophage interaction induces anti-PD1 resistance in hepatocellular carcinoma
por: Lu, Jia-Cheng, et al.
Publicado: (2021)

HDAC2 links ubiquitination to tumor suppression in synovial sarcoma
por: Cooley, Christina, et al.
Publicado: (2021)

Reprogramming of PD-1(+) M2-like tumor-associated macrophages with anti–PD-L1 and lenalidomide in cutaneous T cell lymphoma
por: Han, Zhen, et al.
Publicado: (2023)

Tumor suppression of novel anti–PD-1 antibodies mediated through CD28 costimulatory pathway
por: Fenwick, Craig, et al.
Publicado: (2019)

Anti–PD-1 in Combination With Trametinib Suppresses Tumor Growth and Improves Survival of Intrahepatic Cholangiocarcinoma in Mice
por: Wabitsch, Simon, et al.
Publicado: (2021)

Hedgehog-induced PD-L1 on tumor-associated macrophages is critical for suppression of tumor-infiltrating CD8(+) T cell function
por: Petty, Amy J., et al.
Publicado: (2021)

Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunity
por: Zhong, Wenqun, et al.
Publicado: (2023)

Combining DNMT and HDAC6 inhibitors increases anti-tumor immune signaling and decreases tumor burden in ovarian cancer
por: Moufarrij, Sara, et al.
Publicado: (2020)

Inhibition of tumor‐associated macrophages by trabectedin improves the antitumor adaptive immunity in response to anti‐PD‐1 therapy
por: Belgiovine, Cristina, et al.
Publicado: (2021)

Mannosylated-serum albumin nanoparticle imaging to monitor tumor-associated macrophages under anti-PD1 treatment
por: Gu, Gyo Jeong, et al.
Publicado: (2023)

Lessons learned from the blockade of immune checkpoints in cancer immunotherapy
por: Li, Xiaolei, et al.
Publicado: (2018)

Tumor extracellular vesicles mediate anti-PD-L1 therapy resistance by decoying anti-PD-L1
por: Chen, Jiming, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_8g3vfb95cfn3ggbl4138873fek