Identification of an alpha-1 antitrypsin variant with enhanced specificity for factor XIa by phage display, bacterial expression, and combinatorial mutagenesis

Coagulation Factor XIa (FXIa) is an emerging target for antithrombotic agent development. The M358R variant of the serpin alpha-1 antitrypsin (AAT) inhibits both FXIa and other proteases. Our aim was to enhance the specificity of AAT M358R for FXIa. We randomized two AAT M358R phage display librarie...

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Detalles Bibliográficos
Autores principales: Bhakta, Varsha, Hamada, Mostafa, Nouanesengsy, Amy, Lapierre, Jessica, Perruzza, Darian L., Sheffield, William P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946950/
https://www.ncbi.nlm.nih.gov/pubmed/33692375
http://dx.doi.org/10.1038/s41598-021-84618-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946950/
https://www.ncbi.nlm.nih.gov/pubmed/33692375
http://dx.doi.org/10.1038/s41598-021-84618-7

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