Single-Cell RNA Sequencing and Quantitative Proteomics Analysis Elucidate Marker Genes and Molecular Mechanisms in Hypoplastic Left Heart Patients With Heart Failure

OBJECTIVE: To probe markers and molecular mechanisms of the hypoplastic left heart (HLH) by single-cell RNA sequencing (scRNA-seq) and quantitative proteomics analysis. METHODS: Following data preprocessing, scRNA-seq data of pluripotent stem cell (iPSC)-derived cardiomyocytes from one HLH patient a...

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Detalles Bibliográficos
Autores principales: Ma, Li, Zhou, Na, Zou, Rongjun, Shi, Wanting, Luo, Yuanyuan, Du, Na, Zhong, Jing, Zhao, Xiaodong, Chen, Xinxin, Xia, Huimin, Wu, Yueheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946977/
https://www.ncbi.nlm.nih.gov/pubmed/33718359
http://dx.doi.org/10.3389/fcell.2021.617853

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946977/
https://www.ncbi.nlm.nih.gov/pubmed/33718359
http://dx.doi.org/10.3389/fcell.2021.617853

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