Cargando…

Activation of α7-nAChRs Promotes the Clearance of α-Synuclein and Protects Against Apoptotic Cell Death Induced by Exogenous α-Synuclein Fibrils

Misfolding and abnormal aggregation of α-synuclein (αSyn) have been shown to increase the risk of developing Parkinson's disease (PD). Finding some way to reduce the aggregation of αSyn is particularly important for the treatment of PD. The main route in prion-like αSyn spreading is the choline...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Jifeng, Li, Yun, Li, Yan, Xu, Shi, Tao, Tingting, Hua, Ye, Zhang, Ji, Fan, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947362/ https://www.ncbi.nlm.nih.gov/pubmed/33718373 http://dx.doi.org/10.3389/fcell.2021.637319

Ejemplares similares

Residues Responsible for the Selectivity of α-Conotoxins for Ac-AChBP or nAChRs
por: Lin, Bo, et al.
Publicado: (2016)

The Role of Lipids in the Initiation of α-Synuclein Misfolding
por: Kiechle, Martin, et al.
Publicado: (2020)

The Role of Glial Mitochondria in α-Synuclein Toxicity
por: Jeon, Yu-Mi, et al.
Publicado: (2020)

Editorial: Intracellular Mechanisms of α-Synuclein Processing
por: Zunke, Friederike, et al.
Publicado: (2021)

The Regulation Effect of α7nAChRs and M1AChRs on Inflammation and Immunity in Sepsis
por: Hu, Song, et al.
Publicado: (2021)

“Janus-Faced” α-Synuclein: Role in Parkinson’s Disease
por: Ray, Bipul, et al.
Publicado: (2021)

Characterization of HA-tagged α9 and α10 nAChRs in the mouse cochlea
por: Vyas, Pankhuri, et al.
Publicado: (2020)

Unique Pharmacological Properties of α-Conotoxin OmIA at α7 nAChRs
por: Ho, Thao N.T., et al.
Publicado: (2021)

α-Synuclein-derived lipoparticles in the study of α-Synuclein amyloid fibril formation
por: Falke, Marcel, et al.
Publicado: (2019)

Functionalization of α-synuclein fibrils
por: Povilonienė, Simona, et al.
Publicado: (2015)

Dual Effects of Presynaptic Membrane Mimetics on α-Synuclein Amyloid Aggregation
por: Lin, Yuxi, et al.
Publicado: (2022)

α-Synuclein is required for sperm exocytosis at a post-fusion stage
por: Buzzatto, Micaela Vanina, et al.
Publicado: (2023)

Sulfonium Ligands of the α7 nAChR
por: Horenstein, Nicole A., et al.
Publicado: (2021)

Optical pulse labeling studies reveal exogenous seeding slows α-synuclein clearance
por: Croft, Cara L., et al.
Publicado: (2022)

α-Synuclein fibril-specific nanobody reduces prion-like α-synuclein spreading in mice
por: Butler, Yemima R., et al.
Publicado: (2022)

In Search of Effective Treatments Targeting α-Synuclein Toxicity in Synucleinopathies: Pros and Cons
por: Fouka, Maria, et al.
Publicado: (2020)

Membrane Binding of α-Synuclein Stimulates Expansion of SNARE-Dependent Fusion Pore
por: Khounlo, Ryan, et al.
Publicado: (2021)

α1-nAchR-Mediated Signaling Through Lipid Raft Is Required for Nicotine-Induced NLRP3 Inflammasome Activation and Nicotine-Accelerated Atherosclerosis
por: Duan, Fengqi, et al.
Publicado: (2021)

SLURP-1 Controls Growth and Migration of Lung Adenocarcinoma Cells, Forming a Complex With α7-nAChR and PDGFR/EGFR Heterodimer
por: Bychkov, Maxim L., et al.
Publicado: (2021)

On the Cluster Formation of α-Synuclein Fibrils
por: Dubackic, Marija, et al.
Publicado: (2021)

Monitoring α-synuclein Aggregation Induced by Preformed α-synuclein Fibrils in an In Vitro Model System
por: Kim, Beom Jin, et al.
Publicado: (2023)

Semisynthetic Analogues of Toxiferine I and Their Pharmacological Properties at α7 nAChRs, Muscle-Type nAChRs, and the Allosteric Binding Site of Muscarinic M(2) Receptors
por: Zlotos, Darius P., et al.
Publicado: (2014)

Stimulation of α7-nAChRs coordinates autophagy and apoptosis signaling in experimental knee osteoarthritis
por: Liu, Yuan, et al.
Publicado: (2021)

Farnesyl Transferase Inhibitor Lonafarnib Enhances α7nAChR Expression Through Inhibiting DNA Methylation of CHRNA7 and Increases α7nAChR Membrane Trafficking
por: Chen, Tingting, et al.
Publicado: (2020)

Vagal α7nAChR signaling regulates α7nAChR(+)Sca1(+) cells during lung injury repair
por: Chen, Xiaoyan, et al.
Publicado: (2020)

Quaternary structure of patient-homogenate amplified α-synuclein fibrils modulates seeding of endogenous α-synuclein
por: Frieg, Benedikt, et al.
Publicado: (2022)

α-Synuclein and neuronal cell death
por: Cookson, Mark R
Publicado: (2009)

α-Synuclein and Neuronal Cell Death
por: Yasuda, Toru, et al.
Publicado: (2012)

Studies of lipopolysaccharide effects on the induction of α-synuclein pathology by exogenous fibrils in transgenic mice
por: Rutherford, Nicola J., et al.
Publicado: (2015)

Intracellular A53T Mutant α-Synuclein Impairs Adult Hippocampal Newborn Neuron Integration
por: Regensburger, Martin, et al.
Publicado: (2020)

Imaging of α-Synuclein Aggregates in a Rat Model of Parkinson’s Disease Using Raman Microspectroscopy
por: Sevgi, Fide, et al.
Publicado: (2021)

Modulatory effects of α7 nAChRs on the immune system and its relevance for CNS disorders
por: Kalkman, Hans O., et al.
Publicado: (2016)

Conotoxin Interactions with α9α10-nAChRs: Is the α9α10-Nicotinic Acetylcholine Receptor an Important Therapeutic Target for Pain Management?
por: Mohammadi, Sarasa A., et al.
Publicado: (2015)

Acetylated α-Tubulin and α-Synuclein: Physiological Interplay and Contribution to α-Synuclein Oligomerization
por: Calogero, Alessandra Maria, et al.
Publicado: (2023)

Partial Peptide of α-Synuclein Modified with Small-Molecule Inhibitors Specifically Inhibits Amyloid Fibrillation of α-Synuclein
por: Yoshida, Wataru, et al.
Publicado: (2013)

Partially oxidized DJ-1 inhibits α-synuclein nucleation and remodels mature α-synuclein fibrils in vitro
por: Kumar, Roshan, et al.
Publicado: (2019)

The α-Synuclein Monomer May Have Different Misfolding Mechanisms in the Induction of α-Synuclein Fibrils with Different Polymorphs
por: Zhao, Nannan, et al.
Publicado: (2023)

α-Synuclein liquid condensates fuel fibrillar α-synuclein growth
por: Piroska, Leonard, et al.
Publicado: (2023)

α-Conotoxin as Potential to α7-nAChR Recombinant Expressed in Escherichia coli
por: Liu, Yanli, et al.
Publicado: (2020)

α-Synuclein-112 Impairs Synaptic Vesicle Recycling Consistent With Its Enhanced Membrane Binding Properties
por: Soll, Lindsey G., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_1jfeiq9b3p4g5av8q2h5tqar5a