PD-L1 siRNA Theranostics With a Dextran Nanoparticle Highlights the Importance of Nanoparticle Delivery for Effective Tumor PD-L1 Downregulation

PURPOSE: The inhibition of immune checkpoints such as programmed cell death ligand-1 (PD-L1/CD274) with antibodies is providing novel opportunities to expose cancer cells to the immune system. Antibody based checkpoint blockade can, however, result in serious autoimmune complications because normal...

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Detalles Bibliográficos
Autores principales: Pacheco-Torres, Jesus, Penet, Marie-France, Krishnamachary, Balaji, Mironchik, Yelena, Chen, Zhihang, Bhujwalla, Zaver M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947807/
https://www.ncbi.nlm.nih.gov/pubmed/33718115
http://dx.doi.org/10.3389/fonc.2020.614365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947807/
https://www.ncbi.nlm.nih.gov/pubmed/33718115
http://dx.doi.org/10.3389/fonc.2020.614365

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