Cargando…

Association of NAT2 genetic polymorphism with the efficacy of Neurotropin® for the enhancement of aggrecan gene expression in nucleus pulposus cells: a pilot study

BACKGROUND: Intervertebral disc degeneration, one of the major causes of low-back pain, results from altered biosynthesis/turnover of extracellular matrix in the disc. Previously, we reported that the analgesic drug Neurotropin® (NTP) had an anabolic effect on glycosaminoglycan synthesis in cultured...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nakai, Tomoko, Sakai, Daisuke, Nakamura, Yoshihiko, Horikita, Natsumi, Matsushita, Erika, Naiki, Mitsuru, Watanabe, Masahiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948325/ https://www.ncbi.nlm.nih.gov/pubmed/33706752 http://dx.doi.org/10.1186/s12920-021-00926-x

Ejemplares similares

Upregulation of glycosaminoglycan synthesis by Neurotropin in nucleus pulposus cells via stimulation of chondroitin sulfate N-acetylgalactosaminyltransferase 1: A new approach to attenuation of intervertebral disc degeneration
por: Sakai, Daisuke, et al.
Publicado: (2018)

Effect of Whole Tissue Culture and Basic Fibroblast Growth Factor on Maintenance of Tie2 Molecule Expression in Human Nucleus Pulposus Cells
por: Sako, Kosuke, et al.
Publicado: (2021)

Minimal Sustainability of Dedifferentiation by ROCK Inhibitor on Rat Nucleus Pulposus Cells In Vitro
por: Nukaga, Tadashi, et al.
Publicado: (2019)

Investigation of the Mitigation of DMSO-Induced Cytotoxicity by Hyaluronic Acid following Cryopreservation of Human Nucleus Pulposus Cells
por: Munesada, Daiki, et al.
Publicado: (2023)

Effects of interleukin‐17A in nucleus pulposus cells and its small‐molecule inhibitors for intervertebral disc disease
por: Suyama, Kaori, et al.
Publicado: (2018)

Successful fishing for nucleus pulposus progenitor cells of the intervertebral disc across species
por: Sakai, Daisuke, et al.
Publicado: (2018)

Leptin Downregulates Aggrecan through the p38-ADAMST Pathway in Human Nucleus Pulposus Cells
por: Li, Zheng, et al.
Publicado: (2014)

Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc
por: Sakai, Daisuke, et al.
Publicado: (2012)

Retraction: Leptin Downregulates Aggrecan through the p38-ADAMST Pathway in Human Nucleus Pulposus Cells
Publicado: (2023)

N‐acetylcysteine attenuates oxidative stress‐mediated cell viability loss induced by dimethyl sulfoxide in cryopreservation of human nucleus pulposus cells: A potential solution for mass production
por: Tamagawa, Shota, et al.
Publicado: (2022)

Synergistic role of c-Myc and ERK1/2 in the mitogenic response to TGFβ-1 in cultured rat nucleus pulposus cells
por: Nakai, Tomoko, et al.
Publicado: (2008)

Neurotropin Inhibits Lipid Accumulation by Maintaining Mitochondrial Function in Hepatocytes via AMPK Activation
por: Wang, Qinglan, et al.
Publicado: (2020)

Neurotropin Suppresses Inflammatory Cytokine Expression and Cell Death through Suppression of NF-κB and JNK in Hepatocytes
por: Zhang, Bi, et al.
Publicado: (2014)

Effect of Cryopreservation on Canine and Human Activated Nucleus Pulposus Cells: A Feasibility Study for Cell Therapy of the Intervertebral Disc
por: Tanaka, Masahiro, et al.
Publicado: (2013)

Bag-1 Protects Nucleus Pulposus Cells from Oxidative Stress by Interacting with HSP70
por: Suyama, Kaori, et al.
Publicado: (2023)

Successful treatment of nummular headache with Neurotropin(®)
por: Yamazaki, Yuu, et al.
Publicado: (2011)

CCN family member 2/connective tissue growth factor (CCN2/CTGF) is regulated by Wnt–β-catenin signaling in nucleus pulposus cells
por: Hiyama, Akihiko, et al.
Publicado: (2018)

Wnt3a and wnt5a as Potential Chondrogenic Stimulators for Nucleus Pulposus Cell Induction: A Comprehensive Review
por: Volleman, Tibo Nico Emmie, et al.
Publicado: (2020)

The efficacy of neurotropin in treating patients with nummular headaches
por: Danno, D, et al.
Publicado: (2013)

PKCε Signalling Activates ERK1/2, and Regulates Aggrecan, ADAMTS5, and miR377 Gene Expression in Human Nucleus Pulposus Cells
por: Tsirimonaki, Emmanouella, et al.
Publicado: (2013)

Clinical feature of fibromyalgia syndrome in Japan and novel strategy in the treatment by bioproduct (Neurotropin)
por: Nakamura, H, et al.
Publicado: (2003)

The effects of oxygen tension and antiaging factor Klotho on Wnt signaling in nucleus pulposus cells
por: Hiyama, Akihiko, et al.
Publicado: (2012)

A complex interaction between Wnt signaling and TNF-α in nucleus pulposus cells
por: Hiyama, Akihiko, et al.
Publicado: (2013)

Neurotropin protects rotator cuff tendon cells from lidocaine-induced cell death
por: Abe, Ryunosuke, et al.
Publicado: (2021)

Inducing Angiogenesis in the Nucleus Pulposus
por: Damle, Sheela R., et al.
Publicado: (2023)

Predictive Factors for Successful Treatment of Deep Incisional Surgical Site Infections following Instrumented Spinal Surgeries: Retrospective Review of 1832 Cases
por: Kuroiwa, Masahiro, et al.
Publicado: (2022)

Cytokine expressions of spinal cord injury treated by neurotropin and nafamostat mesylate
por: Sun, Chao, et al.
Publicado: (2021)

Clinical Efficacy of Neurotropin for Lumbar Spinal Stenosis with Low Back Pain
por: Eguchi, Yawara, et al.
Publicado: (2023)

Collagen type II is downregulated in the degenerative nucleus pulposus and contributes to the degeneration and apoptosis of human nucleus pulposus cells
por: Lian, Chengjie, et al.
Publicado: (2017)

Expansion of FGFR3-positive nucleus pulposus cells plays important roles in postnatal nucleus pulposus growth and regeneration
por: Xu, Meng, et al.
Publicado: (2022)

Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells
por: Tekari, Adel, et al.
Publicado: (2016)

The enigma that is the nucleus pulposus cell: the search goes on
por: Erwin, W Mark
Publicado: (2010)

Bone Morphogenetic Proteins for Nucleus Pulposus Regeneration
por: Krouwels, Anita, et al.
Publicado: (2020)

Cell sources proposed for nucleus pulposus regeneration
por: Williams, Rebecca J., et al.
Publicado: (2021)

Alterations of bovine nucleus pulposus cells with aging
por: Molinos, Maria, et al.
Publicado: (2023)

Notochordal and nucleus pulposus marker expression is maintained by sub-populations of adult human nucleus pulposus cells through aging and degeneration
por: Richardson, Stephen M., et al.
Publicado: (2017)

Correction to: Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells
por: Tekari, Adel, et al.
Publicado: (2019)

Neuroprotection by Neurotropin through Crosstalk of Neurotrophic and Innate Immune Receptors in PC12 Cells
por: Fukuda, Yu, et al.
Publicado: (2020)

Nucleus Pulposus Cell Conditioned Medium Promotes Mesenchymal Stem Cell Differentiation into Nucleus Pulposus-Like Cells under Hypoxic Conditions
por: Sinkemani, Arjun, et al.
Publicado: (2020)

Osseous erosion by herniated nucleus pulposus mimicking intraspinal tumor: a case report
por: Yoshioka, Shinji, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_cfsorl5l5oih0kgb6tbajte03i