SRSF3 and SRSF7 modulate 3′UTR length through suppression or activation of proximal polyadenylation sites and regulation of CFIm levels

BACKGROUND: Alternative polyadenylation (APA) refers to the regulated selection of polyadenylation sites (PASs) in transcripts, which determines the length of their 3′ untranslated regions (3′UTRs). We have recently shown that SRSF3 and SRSF7, two closely related SR proteins, connect APA with mRNA e...

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Detalles Bibliográficos
Autores principales: Schwich, Oliver Daniel, Blümel, Nicole, Keller, Mario, Wegener, Marius, Setty, Samarth Thonta, Brunstein, Melinda Elaine, Poser, Ina, Mozos, Igor Ruiz De Los, Suess, Beatrix, Münch, Christian, McNicoll, François, Zarnack, Kathi, Müller-McNicoll, Michaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948361/
https://www.ncbi.nlm.nih.gov/pubmed/33706811
http://dx.doi.org/10.1186/s13059-021-02298-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948361/
https://www.ncbi.nlm.nih.gov/pubmed/33706811
http://dx.doi.org/10.1186/s13059-021-02298-y

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