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Elongin A regulates transcription in vivo through enhanced RNA polymerase processivity

Elongin is an RNA polymerase II (RNAPII)-associated factor that has been shown to stimulate transcriptional elongation in vitro. The Elongin complex is thought to be required for transcriptional induction in response to cellular stimuli and to ubiquitinate RNAPII in response to DNA damage. Yet, the...

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Detalles Bibliográficos
Autores principales: Wang, Yating, Hou, Liming, Ardehali, M. Behfar, Kingston, Robert E., Dynlacht, Brian D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948402/
https://www.ncbi.nlm.nih.gov/pubmed/33298525
http://dx.doi.org/10.1074/jbc.RA120.015876