Molecular mechanism of selective substrate engagement and inhibitor disengagement of cysteine synthase

O-acetyl serine sulfhydrylase (OASS), referred to as cysteine synthase (CS), synthesizes cysteine from O-acetyl serine (OAS) and sulfur in bacteria and plants. The inherent challenge for CS is to overcome 4 to 6 log-folds stronger affinity for its natural inhibitor, serine acetyltransferase (SAT), a...

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Detalles Bibliográficos
Autores principales: Kaushik, Abhishek, Rahisuddin, R., Saini, Neha, Singh, Ravi P., Kaur, Rajveer, Koul, Sukirte, Kumaran, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948407/
https://www.ncbi.nlm.nih.gov/pubmed/33162395
http://dx.doi.org/10.1074/jbc.RA120.014490

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948407/
https://www.ncbi.nlm.nih.gov/pubmed/33162395
http://dx.doi.org/10.1074/jbc.RA120.014490

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