Repurposing p97 inhibitors for chemical modulation of the bacterial ClpB–DnaK bichaperone system

The ClpB–DnaK bichaperone system reactivates aggregated cellular proteins and is essential for survival of bacteria, fungi, protozoa, and plants under stress. AAA+ ATPase ClpB is a promising target for the development of antimicrobials because a loss of its activity is detrimental for survival of ma...

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Detalles Bibliográficos
Autores principales: Glaza, Przemyslaw, Ranaweera, Chathurange B., Shiva, Sunitha, Roy, Anuradha, Geisbrecht, Brian V., Schoenen, Frank J., Zolkiewski, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948422/
https://www.ncbi.nlm.nih.gov/pubmed/33187983
http://dx.doi.org/10.1074/jbc.RA120.015413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948422/
https://www.ncbi.nlm.nih.gov/pubmed/33187983
http://dx.doi.org/10.1074/jbc.RA120.015413

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