Cargando…

Repurposing p97 inhibitors for chemical modulation of the bacterial ClpB–DnaK bichaperone system

The ClpB–DnaK bichaperone system reactivates aggregated cellular proteins and is essential for survival of bacteria, fungi, protozoa, and plants under stress. AAA+ ATPase ClpB is a promising target for the development of antimicrobials because a loss of its activity is detrimental for survival of ma...

Descripción completa

Detalles Bibliográficos
Autores principales:	Glaza, Przemyslaw, Ranaweera, Chathurange B., Shiva, Sunitha, Roy, Anuradha, Geisbrecht, Brian V., Schoenen, Frank J., Zolkiewski, Michal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948422/ https://www.ncbi.nlm.nih.gov/pubmed/33187983 http://dx.doi.org/10.1074/jbc.RA120.015413

Ejemplares similares

Activation of the DnaK-ClpB Complex is Regulated by the Properties of the Bound Substrate
por: Fernández-Higuero, Jose Angel, et al.
Publicado: (2018)

Hsp100 Molecular Chaperone ClpB and Its Role in Virulence of Bacterial Pathogens
por: Kędzierska-Mieszkowska, Sabina, et al.
Publicado: (2021)

Aggregate-Reactivation Activity of the Molecular Chaperone ClpB from Ehrlichia chaffeensis
por: Zhang, Ting, et al.
Publicado: (2013)

Characterization of the molecular chaperone ClpB from the pathogenic spirochaete Leptospira interrogans
por: Krajewska, Joanna, et al.
Publicado: (2017)

Structural basis for aggregate dissolution and refolding by the Mycobacterium tuberculosis ClpB-DnaK bi-chaperone system
por: Yin, Yanting, et al.
Publicado: (2021)

Immunoreactivity of the AAA+ chaperone ClpB from Leptospira interrogans with sera from Leptospira-infected animals
por: Krajewska, Joanna, et al.
Publicado: (2016)

Isolation and Identification of Putative Protein Substrates of the AAA+ Molecular Chaperone ClpB from the Pathogenic Spirochaete Leptospira interrogans
por: Krajewska, Joanna, et al.
Publicado: (2018)

Substrate Discrimination by ClpB and Hsp104
por: Johnston, Danielle M., et al.
Publicado: (2017)

Genome-wide analysis of rice ClpB/HSP100, ClpC and ClpD genes
por: Singh, Amanjot, et al.
Publicado: (2010)

The Role of ClpB in Bacterial Stress Responses and Virulence
por: Alam, Athar, et al.
Publicado: (2021)

The Bacterial ClpXP-ClpB Family Is Enriched with RNA-Binding Protein Complexes
por: Auburger, Georg, et al.
Publicado: (2022)

Mutant Analysis Reveals Allosteric Regulation of ClpB Disaggregase
por: Franke, Kamila B., et al.
Publicado: (2017)

Comparative roles of clpA and clpB in the survival of S. Typhimurium under stress and virulence in poultry
por: Sangpuii, Lal, et al.
Publicado: (2018)

Dietary flavonoid fisetin binds human SUMO1 and blocks sumoylation of p53
por: Velazhahan, Vaithish, et al.
Publicado: (2020)

Escherichia coli ClpB is a non-processive polypeptide translocase
por: Li, Tao, et al.
Publicado: (2015)

Dynamic structural states of ClpB involved in its disaggregation function
por: Uchihashi, Takayuki, et al.
Publicado: (2018)

Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase
por: Rizo, Alexandrea N., et al.
Publicado: (2019)

Dissociation between the critical role of ClpB of Francisella tularensis for the heat shock response and the DnaK interaction and its important role for efficient type VI secretion and bacterial virulence
por: Alam, Athar, et al.
Publicado: (2020)

TLR2 Signaling is Required for the Innate, but Not Adaptive Response to LVS clpB
por: Roberts, Lydia M., et al.
Publicado: (2014)

Prion propagation can occur in a prokaryote and requires the ClpB chaperone
por: Yuan, Andy H, et al.
Publicado: (2014)

ATP hydrolysis-coupled peptide translocation mechanism of Mycobacterium tuberculosis ClpB
por: Yu, Hongjun, et al.
Publicado: (2018)

Role of ClpB From Corynebacterium crenatum in Thermal Stress and Arginine Fermentation
por: Huang, Mingzhu, et al.
Publicado: (2020)

Collagen-Like Proteins (ClpA, ClpB, ClpC, and ClpD) Are Required for Biofilm Formation and Adhesion to Plant Roots by Bacillus amyloliquefaciens FZB42
por: Zhao, Xia, et al.
Publicado: (2015)

Comparative Analysis of the Structure and Function of AAA+ Motors ClpA, ClpB, and Hsp104: Common Threads and Disparate Functions
por: Duran, Elizabeth C., et al.
Publicado: (2017)

Publisher Correction: Dynamic structural states of ClpB involved in its disaggregation function
por: Uchihashi, Takayuki, et al.
Publicado: (2019)

The Symbiotic Performance of Chickpea Rhizobia Can Be Improved by Additional Copies of the clpB Chaperone Gene
por: Paço, Ana, et al.
Publicado: (2016)

New insights into structural and functional relationships between LonA proteases and ClpB chaperones
por: Rotanova, Tatyana V., et al.
Publicado: (2019)

Phylogenetic and expression dynamics of tomato ClpB/Hsp100 gene under heat stress
por: Gul, Sanober, et al.
Publicado: (2021)

Two-Step Activation Mechanism of the ClpB Disaggregase for Sequential Substrate Threading by the Main ATPase Motor
por: Deville, Célia, et al.
Publicado: (2019)

Francisella requires dynamic type VI secretion system and ClpB to deliver effectors for phagosomal escape
por: Brodmann, Maj, et al.
Publicado: (2017)

Retraction: Phylogenetic and expression dynamics of tomato ClpB/Hsp100 gene under heat stress
Publicado: (2023)

ClpB mutants of Francisella tularensis subspecies holarctica and tularensis are defective for type VI secretion and intracellular replication
por: Alam, Athar, et al.
Publicado: (2018)

AAA+ Molecular Chaperone ClpB in Leptospira interrogans: Its Role and Significance in Leptospiral Virulence and Pathogenesis of Leptospirosis
por: Kędzierska-Mieszkowska, Sabina, et al.
Publicado: (2020)

Reconstruction of Three-Dimensional Conformations of Bacterial ClpB from High-Speed Atomic-Force-Microscopy Images
por: Dasgupta, Bhaskar, et al.
Publicado: (2021)

Backbone chemical shift assignment and dynamics of the N-terminal domain of ClpB from Francisella tularensis type VI secretion system
por: Mushtaq, Ameeq Ul, et al.
Publicado: (2022)

Head-to-tail interactions of the coiled-coil domains regulate ClpB activity and cooperation with Hsp70 in protein disaggregation
por: Carroni, Marta, et al.
Publicado: (2014)

trans-Acting Arginine Residues in the AAA+ Chaperone ClpB Allosterically Regulate the Activity through Inter- and Intradomain Communication
por: Zeymer, Cathleen, et al.
Publicado: (2014)

Bacterial ClpB heat-shock protein, an antigen-mimetic of the anorexigenic peptide α-MSH, at the origin of eating disorders
por: Tennoune, N, et al.
Publicado: (2014)

Gut bacterial ClpB-like gene function is associated with decreased body weight and a characteristic microbiota profile
por: Arnoriaga-Rodríguez, María, et al.
Publicado: (2020)

Host Starvation and Female Sex Influence Enterobacterial ClpB Production: A Possible Link to the Etiology of Eating Disorders
por: Breton, Jonathan, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_cqrhnfo9e2hano417ah85fvrik