Cargando…
USP13 interacts with cohesin and regulates its ubiquitination in human cells
Cohesin is a multiprotein ring complex that regulates 3D genome organization, sister chromatid cohesion, gene expression, and DNA repair. Cohesin is known to be ubiquitinated, although the mechanism, regulation, and effects of cohesin ubiquitination remain poorly defined. We previously used gene edi...
Autores principales: | He, Xiaoyuan, Kim, Jung-Sik, Diaz-Martinez, Laura A., Han, Cecil, Lane, William S., Budnik, Bogdan, Waldman, Todd |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948425/ https://www.ncbi.nlm.nih.gov/pubmed/33334891 http://dx.doi.org/10.1074/jbc.RA120.015762 |
Ejemplares similares
-
Cohesin gene mutations in tumorigenesis: from discovery to clinical significance
por: Solomon, David A., et al.
Publicado: (2014) -
USP13 promotes development and metastasis of high-grade serous ovarian carcinoma in a novel mouse model
por: Kwon, Juntae, et al.
Publicado: (2022) -
Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36
por: O’Dea, Rachel, et al.
Publicado: (2023) -
Interallelic complementation provides functional evidence for cohesin–cohesin interactions on DNA
por: Eng, Thomas, et al.
Publicado: (2015) -
Amplification of USP13 drives ovarian cancer metabolism
por: Han, Cecil, et al.
Publicado: (2016)