The evolution and mechanism of GPCR proton sensing

Of the 800 G protein–coupled receptors (GPCRs) in humans, only three (GPR4, GPR65, and GPR68) regulate signaling in acidified microenvironments by sensing protons (H(+)). How these receptors have uniquely obtained this ability is unknown. Here, we show these receptors evolved the capability to sense...

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Detalles Bibliográficos
Autores principales: Rowe, Jacob B., Kapolka, Nicholas J., Taghon, Geoffrey J., Morgan, William M., Isom, Daniel G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948426/
https://www.ncbi.nlm.nih.gov/pubmed/33478938
http://dx.doi.org/10.1074/jbc.RA120.016352

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948426/
https://www.ncbi.nlm.nih.gov/pubmed/33478938
http://dx.doi.org/10.1074/jbc.RA120.016352

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