Identification of a druggable protein–protein interaction site between mutant p53 and its stabilizing chaperone DNAJA1

The TP53 gene is the most frequently mutated gene in human cancers, and the majority of TP53 mutations are missense mutations. As a result, these mutant p53 (mutp53) either directly lose wildtype p53 (wtp53) tumor suppressor function or exhibit a dominant negative effect over wtp53. In addition, som...

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Detalles Bibliográficos
Autores principales: Tong, Xin, Xu, Dandan, Mishra, Rama K., Jones, Ryan D., Sun, Leyu, Schiltz, Gary E., Liao, Jie, Yang, Guang-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948449/
https://www.ncbi.nlm.nih.gov/pubmed/33208462
http://dx.doi.org/10.1074/jbc.RA120.014749

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948449/
https://www.ncbi.nlm.nih.gov/pubmed/33208462
http://dx.doi.org/10.1074/jbc.RA120.014749

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