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Identification of a druggable protein–protein interaction site between mutant p53 and its stabilizing chaperone DNAJA1
The TP53 gene is the most frequently mutated gene in human cancers, and the majority of TP53 mutations are missense mutations. As a result, these mutant p53 (mutp53) either directly lose wildtype p53 (wtp53) tumor suppressor function or exhibit a dominant negative effect over wtp53. In addition, som...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948449/ https://www.ncbi.nlm.nih.gov/pubmed/33208462 http://dx.doi.org/10.1074/jbc.RA120.014749 |