Ancestral reconstruction of mammalian FMO1 enables structural determination, revealing unique features that explain its catalytic properties

Mammals rely on the oxidative flavin-containing monooxygenases (FMOs) to detoxify numerous and potentially deleterious xenobiotics; this activity extends to many drugs, giving FMOs high pharmacological relevance. However, our knowledge regarding these membrane-bound enzymes has been greatly impeded...

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Detalles Bibliográficos
Autores principales: Bailleul, Gautier, Nicoll, Callum R., Mascotti, María Laura, Mattevi, Andrea, Fraaije, Marco W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948450/
https://www.ncbi.nlm.nih.gov/pubmed/33759784
http://dx.doi.org/10.1074/jbc.RA120.016297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948450/
https://www.ncbi.nlm.nih.gov/pubmed/33759784
http://dx.doi.org/10.1074/jbc.RA120.016297

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