A conserved acetylation switch enables pharmacological control of tubby-like protein stability

Tubby-like proteins (TULPs) are characterized by a conserved C-terminal domain that binds phosphoinositides. Collectively, mammalian TULP1-4 proteins play essential roles in intracellular transport, cell differentiation, signaling, and motility. Yet, little is known about how the function of these p...

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Detalles Bibliográficos
Autores principales: Kerek, Evan M., Yoon, Kevin H., Luo, Shu Y., Chen, Jerry, Valencia, Robert, Julien, Olivier, Waskiewicz, Andrew J., Hubbard, Basil P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948452/
https://www.ncbi.nlm.nih.gov/pubmed/33187986
http://dx.doi.org/10.1074/jbc.RA120.015839

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948452/
https://www.ncbi.nlm.nih.gov/pubmed/33187986
http://dx.doi.org/10.1074/jbc.RA120.015839

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