Cargando…

A conserved acetylation switch enables pharmacological control of tubby-like protein stability

Tubby-like proteins (TULPs) are characterized by a conserved C-terminal domain that binds phosphoinositides. Collectively, mammalian TULP1-4 proteins play essential roles in intracellular transport, cell differentiation, signaling, and motility. Yet, little is known about how the function of these p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kerek, Evan M., Yoon, Kevin H., Luo, Shu Y., Chen, Jerry, Valencia, Robert, Julien, Olivier, Waskiewicz, Andrew J., Hubbard, Basil P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948452/ https://www.ncbi.nlm.nih.gov/pubmed/33187986 http://dx.doi.org/10.1074/jbc.RA120.015839

Ejemplares similares

The tubby family proteins
por: Mukhopadhyay, Saikat, et al.
Publicado: (2011)

Cilia, tubby mice, and obesity
por: Mukhopadhyay, Saikat, et al.
Publicado: (2013)

Tubby proteins prove their adaptability
por: Short, Ben
Publicado: (2017)

C-terminally mutated tubby protein accumulates in aggresomes
por: Kim, Sunshin, et al.
Publicado: (2017)

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins
por: Badgandi, Hemant B., et al.
Publicado: (2017)

S.E.M. Roger W. Tubby
por: CERN Press Office. Geneva
Publicado: (1962)

Differential Roles of Tubby Family Proteins in Ciliary Formation and Trafficking
por: Hong, Julie J., et al.
Publicado: (2021)

Drosophila king tubby (ktub) mediates light-induced rhodopsin endocytosis and retinal degeneration
por: Chen, Shu-Fen, et al.
Publicado: (2012)

Tubby is required for trafficking G protein-coupled receptors to neuronal cilia
por: Sun, Xun, et al.
Publicado: (2012)

Distribution of ciliary adaptor proteins tubby and TULP3 in the organ of Corti
por: Lindner, Laura A., et al.
Publicado: (2023)

Acute exercise reduces feeding by activating IL-6/Tubby axis in the mouse hypothalamus
por: de Oliveira Micheletti, Thayana, et al.
Publicado: (2022)

Genome-Wide Identification and Expression Analysis of the Tubby-Like Protein Family in the Malus domestica Genome
por: Xu, Jia-Ning, et al.
Publicado: (2016)

Insulin Phosphorylates Tyrosine Residue 464 of Tub and Translocates Tubby into the Nucleus in HIRcB Cells
por: Kim, Jin Wook, et al.
Publicado: (2014)

The Caenorhabditis elegans Tubby homolog dynamically modulates olfactory cilia membrane morphogenesis and phospholipid composition
por: DiTirro, Danielle, et al.
Publicado: (2019)

Decrypting tubby-like protein gene family of multiple functions in starch root crop cassava
por: Dong, Ming-You, et al.
Publicado: (2019)

Genome-wide identification and comprehensive analysis of tubby-like protein gene family in multiple crops
por: Zeng, Yafei, et al.
Publicado: (2022)

Phospholipid scramblases and Tubby-like proteins belong to a new superfamily of membrane tethered transcription factors
por: Bateman, Alex, et al.
Publicado: (2009)

dTULP, the Drosophila melanogaster Homolog of Tubby, Regulates Transient Receptor Potential Channel Localization in Cilia
por: Park, Jina, et al.
Publicado: (2013)

Genome-wide identification of the Tubby-Like Protein (TLPs) family in medicinal model plant Salvia miltiorrhiza
por: Wang, Kai, et al.
Publicado: (2021)

Two cooperative binding sites sensitize PI(4,5)P(2) recognition by the tubby domain
por: Thallmair, Veronika, et al.
Publicado: (2022)

Comprehensive Profiling of Tubby-Like Protein Expression Uncovers Ripening-Related TLP Genes in Tomato (Solanum lycopersicum)
por: Zhang, Yaoxin, et al.
Publicado: (2020)

Comprehensive Profiling of Tubby-Like Proteins in Soybean and Roles of the GmTLP8 Gene in Abiotic Stress Responses
por: Xu, Hong-Ru, et al.
Publicado: (2022)

Improvement of plant tolerance to drought stress by cotton tubby-like protein 30 through stomatal movement regulation
por: Li, Zhanshuai, et al.
Publicado: (2022)

The expression of a tubby-like protein from Malus domestica (MdTLP7) enhances abiotic stress tolerance in Arabidopsis
por: Xu, Jianing, et al.
Publicado: (2019)

Interactions between TULP3 tubby domain and ARL13B amphipathic helix promote lipidated protein transport to cilia
por: Palicharla, Vivek Reddy, et al.
Publicado: (2023)

MicroRNA-506 has a suppressive effect on the tumorigenesis of nonsmall-cell lung cancer by regulating tubby-like protein 3
por: Li, Zhan-Hua, et al.
Publicado: (2021)

Microtubule-associated protein 1 A and tubby act independently in regulating the localization of stereocilin to the tips of inner ear hair cell stereocilia
por: Youn, Song Yi, et al.
Publicado: (2022)

Genome-Wide Identification, Characterization, and Expression Analysis of Tubby-like Protein (TLP) Gene Family Members in Woodland Strawberry (Fragaria vesca)
por: Li, Shuangtao, et al.
Publicado: (2022)

ALG-2-interacting Tubby-like protein superfamily member PLSCR3 is secreted by an exosomal pathway and taken up by recipient cultured cells
por: Inuzuka, Tatsutoshi, et al.
Publicado: (2013)

Genome-Wide Identification and Evolutionary Analysis of Gossypium Tubby-Like Protein (TLP) Gene Family and Expression Analyses During Salt and Drought Stress
por: Bano, Nasreen, et al.
Publicado: (2021)

Non-catalytic allostery in α-TAT1 by a phospho-switch drives dynamic microtubule acetylation
por: Deb Roy, Abhijit, et al.
Publicado: (2022)

A tubby-like protein CsTLP8 acts in the ABA signaling pathway and negatively regulates osmotic stresses tolerance during seed germination
por: Li, Shuangtao, et al.
Publicado: (2021)

Localization of the tubby domain, a PI(4,5)P(2) biosensor, to E-Syt3-rich endoplasmic reticulum–plasma membrane junctions
por: Thallmair, Veronika, et al.
Publicado: (2023)

An acetylation–phosphorylation switch that regulates tau aggregation propensity and function
por: Carlomagno, Yari, et al.
Publicado: (2017)

Histone chaperone exploits intrinsic disorder to switch acetylation specificity
por: Danilenko, Nataliya, et al.
Publicado: (2019)

Acetylation turns leucine into a drug by membrane transporter switching
por: Churchill, Grant C., et al.
Publicado: (2021)

Modulation of plant acetyl-CoA synthetase activity by post-translational lysine acetylation
por: Sofeo, Naazneen, et al.
Publicado: (2023)

VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis
por: Chen, Jiahuan, et al.
Publicado: (2017)

Effects of α-tubulin acetylation on microtubule structure and stability
por: Eshun-Wilson, Lisa, et al.
Publicado: (2019)

4-Acetylpiperazinium picrate
por: Kavitha, Channappa N., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_ftej6cuuhhrr85nma3nakib3qe