Novel drug discovery platform for spinocerebellar ataxia, using fluorescence technology targeting β-III-spectrin

Numerous diseases are linked to mutations in the actin-binding domains (ABDs) of conserved cytoskeletal proteins, including β-III-spectrin, α-actinin, filamin, and dystrophin. A β-III-spectrin ABD mutation (L253P) linked to spinocerebellar ataxia type 5 (SCA5) causes a dramatic increase in actin bin...

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Detalles Bibliográficos
Autores principales: Rebbeck, Robyn T., Andrick, Anna K., Denha, Sarah A., Svensson, Bengt, Guhathakurta, Piyali, Thomas, David D., Hays, Thomas S., Avery, Adam W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948455/
https://www.ncbi.nlm.nih.gov/pubmed/33839680
http://dx.doi.org/10.1074/jbc.RA120.015417

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948455/
https://www.ncbi.nlm.nih.gov/pubmed/33839680
http://dx.doi.org/10.1074/jbc.RA120.015417

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