A cell competition–based small molecule screen identifies a novel compound that induces dual c-Myc depletion and p53 activation

Breakpoint Cluster Region-Abelson kinase (BCR–Abl) is a driver oncogene that causes chronic myeloid leukemia and a subset of acute lymphoid leukemias. Although tyrosine kinase inhibitors provide an effective treatment for these diseases, they generally do not kill leukemic stem cells (LSCs), the can...

Descripción completa

Detalles Bibliográficos
Autores principales: Tadele, Dagim Shiferaw, Robertson, Joseph, Crispin, Richard, Herrera, Maria C., Chlubnová, Markéta, Piechaczyk, Laure, Ayuda-Durán, Pilar, Singh, Sachin Kumar, Gedde-Dahl, Tobias, Fløisand, Yngvar, Skavland, Jørn, Wesche, Jørgen, Gjertsen, Bjørn-Tore, Enserink, Jorrit M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948465/
https://www.ncbi.nlm.nih.gov/pubmed/33303632
http://dx.doi.org/10.1074/jbc.RA120.015285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948465/
https://www.ncbi.nlm.nih.gov/pubmed/33303632
http://dx.doi.org/10.1074/jbc.RA120.015285

Ejemplares similares