A cell competition–based small molecule screen identifies a novel compound that induces dual c-Myc depletion and p53 activation

Breakpoint Cluster Region-Abelson kinase (BCR–Abl) is a driver oncogene that causes chronic myeloid leukemia and a subset of acute lymphoid leukemias. Although tyrosine kinase inhibitors provide an effective treatment for these diseases, they generally do not kill leukemic stem cells (LSCs), the can...

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Detalles Bibliográficos
Autores principales: Tadele, Dagim Shiferaw, Robertson, Joseph, Crispin, Richard, Herrera, Maria C., Chlubnová, Markéta, Piechaczyk, Laure, Ayuda-Durán, Pilar, Singh, Sachin Kumar, Gedde-Dahl, Tobias, Fløisand, Yngvar, Skavland, Jørn, Wesche, Jørgen, Gjertsen, Bjørn-Tore, Enserink, Jorrit M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948465/
https://www.ncbi.nlm.nih.gov/pubmed/33303632
http://dx.doi.org/10.1074/jbc.RA120.015285

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