Synthetic thick filaments: A new avenue for better understanding the myosin super-relaxed state in healthy, diseased, and mavacamten-treated cardiac systems

A hallmark feature of myosin-II is that it can spontaneously self-assemble into bipolar synthetic thick filaments (STFs) in low-ionic-strength buffers, thereby serving as a reconstituted in vitro model for muscle thick filaments. Although these STFs have been extensively used for structural characte...

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Detalles Bibliográficos
Autores principales: Gollapudi, Sampath K., Yu, Ming, Gan, Qing-Fen, Nag, Suman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948491/
https://www.ncbi.nlm.nih.gov/pubmed/33234590
http://dx.doi.org/10.1074/jbc.RA120.016506

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948491/
https://www.ncbi.nlm.nih.gov/pubmed/33234590
http://dx.doi.org/10.1074/jbc.RA120.016506

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