Optimization of a peptide ligand for the adhesion GPCR ADGRG2 provides a potent tool to explore receptor biology

The adhesion GPCR ADGRG2, also known as GPR64, is a critical regulator of male fertility that maintains ion/pH homeostasis and CFTR coupling. The molecular basis of ADGRG2 function is poorly understood, in part because no endogenous ligands for ADGRG2 have been reported, thus limiting the tools avai...

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Detalles Bibliográficos
Autores principales: Sun, Yujing, Zhang, Daolai, Ma, Ming-Liang, Lin, Hui, Song, Youchen, Wang, Junyan, Ma, Chuanshun, Yu, Ke, An, Wentao, Guo, Shengchao, He, Dongfang, Yang, Zhao, Xiao, Peng, Hou, Guige, Yu, Xiao, Sun, Jin-Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948503/
https://www.ncbi.nlm.nih.gov/pubmed/33303626
http://dx.doi.org/10.1074/jbc.RA120.014726

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