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CRAC channel opening is determined by a series of Orai1 gating checkpoints in the transmembrane and cytosolic regions
The initial activation step in the gating of ubiquitously expressed Orai1 calcium (Ca(2+)) ion channels represents the activation of the Ca(2+)-sensor protein STIM1 upon Ca(2+) store depletion of the endoplasmic reticulum. Previous studies using constitutively active Orai1 mutants gave rise to, but...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948504/ https://www.ncbi.nlm.nih.gov/pubmed/33361160 http://dx.doi.org/10.1074/jbc.RA120.015548 |