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Respiratory FimA-Specific Secretory IgA Antibodies Upregulated by DC-Targeting Nasal Double DNA Adjuvant Are Essential for Elimination of Porphyromonas gingivalis
Our previous studies showed that a combination of a DNA plasmid encoding Flt3 ligand (pFL) and CpG oligodeoxynucleotides 1826 (CpG ODN) (FL/CpG) as a nasal adjuvant provoked antigen-specific immune responses. In this study, we investigated the efficacy of a nasal vaccine consisting of FimA as the st...
Autores principales: | Kataoka, Kosuke, Kawabata, Shigetada, Koyanagi, Kayo, Hashimoto, Yoshiya, Miyake, Tatsuro, Fujihashi, Kohtaro |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948520/ https://www.ncbi.nlm.nih.gov/pubmed/33717178 http://dx.doi.org/10.3389/fimmu.2021.634923 |
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