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A new FRET-based platform to track substrate ubiquitination by fluorescence

Post-translational modification of protein by ubiquitin (Ub) alters the stability, subcellular location, or function of the target protein, thereby impacting numerous biological processes and directly contributing to myriad cellular defects or disease states, such as cancer. Tracking substrate ubiqu...

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Detalles Bibliográficos
Autores principales: Wu, Kenneth, Ching, Kevin, Chong, Robert A., Pan, Zhen-Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948536/
https://www.ncbi.nlm.nih.gov/pubmed/33361156
http://dx.doi.org/10.1074/jbc.RA120.016858