Regulation of factor V and factor V-short by TFPIα: Relationship between B-domain proteolysis and binding

Coagulation factor V (FV) plays an anticoagulant role but serves as a procoagulant cofactor in the prothrombinase complex once activated to FVa. At the heart of these opposing effects is the proteolytic removal of its central B-domain, including conserved functional landmarks (basic region, BR; 963–...

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Detalles Bibliográficos
Autores principales: Petrillo, Teodolinda, Ayombil, Francis, van’t Veer, Cornelis, Camire, Rodney M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948760/
https://www.ncbi.nlm.nih.gov/pubmed/33376137
http://dx.doi.org/10.1074/jbc.RA120.016341

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948760/
https://www.ncbi.nlm.nih.gov/pubmed/33376137
http://dx.doi.org/10.1074/jbc.RA120.016341

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