Familial Alzheimer’s disease mutations in amyloid protein precursor alter proteolysis by γ-secretase to increase amyloid β-peptides of ≥45 residues

Production of amyloid β-protein (Aβ) is carried out by the membrane-embedded γ-secretase complex. Mutations in the transmembrane domain of amyloid β-protein precursor (APP) associated with early-onset familial Alzheimer's disease (FAD) can alter the ratio of aggregation-prone 42-residue Aβ (Aβ4...

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Detalles Bibliográficos
Autores principales: Devkota, Sujan, Williams, Todd D., Wolfe, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948801/
https://www.ncbi.nlm.nih.gov/pubmed/33450230
http://dx.doi.org/10.1016/j.jbc.2021.100281

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948801/
https://www.ncbi.nlm.nih.gov/pubmed/33450230
http://dx.doi.org/10.1016/j.jbc.2021.100281

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