Enzymatic characterization of three human RNA adenosine methyltransferases reveals diverse substrate affinities and reaction optima

RNA methylations of varied RNA species (mRNA, tRNA, rRNA, non-coding RNA) generate a range of modified nucleotides, including N6-methyladenosine. Here we study the enzymology of three human RNA methyltransferases that methylate the adenosine amino group in diverse contexts, when it is: the first tra...

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Detalles Bibliográficos
Autores principales: Yu, Dan, Kaur, Gundeep, Blumenthal, Robert M., Zhang, Xing, Cheng, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948815/
https://www.ncbi.nlm.nih.gov/pubmed/33428944
http://dx.doi.org/10.1016/j.jbc.2021.100270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948815/
https://www.ncbi.nlm.nih.gov/pubmed/33428944
http://dx.doi.org/10.1016/j.jbc.2021.100270

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