The muscle-relaxing C-terminal peptide from troponin I populates a nascent helix, facilitating binding to tropomyosin with a potent therapeutic effect

The conserved C-terminal end segment of troponin I (TnI) plays a critical role in regulating muscle relaxation. This function is retained in the isolated C-terminal 27 amino acid peptide (residues 184–210) of human cardiac TnI (HcTnI-C27): When added to skinned muscle fibers, HcTnI-C27 reduces the C...

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Detalles Bibliográficos
Autores principales: Hornos, Felipe, Feng, Han-Zhong, Rizzuti, Bruno, Palomino-Schätzlein, Martina, Wieczorek, David, Neira, José L., Jin, J.-P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948816/
https://www.ncbi.nlm.nih.gov/pubmed/33814345
http://dx.doi.org/10.1074/jbc.RA120.016012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948816/
https://www.ncbi.nlm.nih.gov/pubmed/33814345
http://dx.doi.org/10.1074/jbc.RA120.016012

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