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The muscle-relaxing C-terminal peptide from troponin I populates a nascent helix, facilitating binding to tropomyosin with a potent therapeutic effect

The conserved C-terminal end segment of troponin I (TnI) plays a critical role in regulating muscle relaxation. This function is retained in the isolated C-terminal 27 amino acid peptide (residues 184–210) of human cardiac TnI (HcTnI-C27): When added to skinned muscle fibers, HcTnI-C27 reduces the C...

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Detalles Bibliográficos
Autores principales:	Hornos, Felipe, Feng, Han-Zhong, Rizzuti, Bruno, Palomino-Schätzlein, Martina, Wieczorek, David, Neira, José L., Jin, J.-P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948816/ https://www.ncbi.nlm.nih.gov/pubmed/33814345 http://dx.doi.org/10.1074/jbc.RA120.016012

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