Loss of Smi1, a protein involved in cell wall synthesis, extends replicative life span by enhancing rDNA stability in Saccharomyces cerevisiae

In Saccharomyces cerevisiae, replicative life span (RLS) is primarily affected by the stability of ribosomal DNA (rDNA). The stability of the highly repetitive rDNA array is maintained through transcriptional silencing by the NAD(+)-dependent histone deacetylase Sir2. Recently, the loss of Smi1, a p...

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Detalles Bibliográficos
Autores principales: Hong, Sujin, Huh, Won-Ki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948926/
https://www.ncbi.nlm.nih.gov/pubmed/33837734
http://dx.doi.org/10.1016/j.jbc.2021.100258

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948926/
https://www.ncbi.nlm.nih.gov/pubmed/33837734
http://dx.doi.org/10.1016/j.jbc.2021.100258

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