A clinically relevant polymorphism in the Na(+)/taurocholate cotransporting polypeptide (NTCP) occurs at a rheostat position

Conventionally, most amino acid substitutions at “important” protein positions are expected to abolish function. However, in several soluble-globular proteins, we identified a class of nonconserved positions for which various substitutions produced progressive functional changes; we consider these e...

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Detalles Bibliográficos
Autores principales: Ruggiero, Melissa J., Malhotra, Shipra, Fenton, Aron W., Swint-Kruse, Liskin, Karanicolas, John, Hagenbuch, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948949/
https://www.ncbi.nlm.nih.gov/pubmed/33168628
http://dx.doi.org/10.1074/jbc.RA120.014889

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948949/
https://www.ncbi.nlm.nih.gov/pubmed/33168628
http://dx.doi.org/10.1074/jbc.RA120.014889

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