The antiretroviral 2′,3′-dideoxycytidine causes mitochondrial dysfunction in proliferating and differentiated HepaRG human cell cultures

Nucleoside reverse transcriptase inhibitors (NRTIs) were the first drugs used to treat human immunodeficiency virus infection, and their use can cause mitochondrial toxicity, including mitochondrial DNA (mtDNA) depletion in several cases. The first-generation NRTIs, including 2′,3′-dideoxycytidine (...

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Detalles Bibliográficos
Autores principales: Young, Carolyn K.J., Wheeler, Joel H., Rahman, Md. Mostafijur, Young, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948951/
https://www.ncbi.nlm.nih.gov/pubmed/33334881
http://dx.doi.org/10.1074/jbc.RA120.014885

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948951/
https://www.ncbi.nlm.nih.gov/pubmed/33334881
http://dx.doi.org/10.1074/jbc.RA120.014885

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