Cargando…

The ATPase mechanism of myosin 15, the molecular motor mutated in DFNB3 human deafness

Cochlear hair cells each possess an exquisite bundle of actin-based stereocilia that detect sound. Unconventional myosin 15 (MYO15) traffics and delivers critical molecules required for stereocilia development and thus is essential for building the mechanosensory hair bundle. Mutations in the human...

Descripción completa

Detalles Bibliográficos
Autores principales: Jiang, Fangfang, Takagi, Yasuharu, Shams, Arik, Heissler, Sarah M., Friedman, Thomas B., Sellers, James R., Bird, Jonathan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948958/
https://www.ncbi.nlm.nih.gov/pubmed/33372036
http://dx.doi.org/10.1074/jbc.RA120.014903