A conformation-specific antibody against oligomeric β-amyloid restores neuronal integrity in a mouse model of Alzheimer's disease

Conformationally distinct aggregates of the amyloid β (Aβ) peptide accumulate in brains of patients with Alzheimer's disease (AD), but the roles of the different aggregates in disease progression are not clear. We previously isolated two single-chain variable domain antibody fragments (scFvs),...

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Detalles Bibliográficos
Autores principales: He, Ping, Schulz, Philip, Sierks, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948963/
https://www.ncbi.nlm.nih.gov/pubmed/33376140
http://dx.doi.org/10.1074/jbc.RA120.015327

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948963/
https://www.ncbi.nlm.nih.gov/pubmed/33376140
http://dx.doi.org/10.1074/jbc.RA120.015327

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