Cryptic prokaryotic promoters explain instability of recombinant neuronal sodium channels in bacteria

Mutations in genes encoding the human-brain-expressed voltage-gated sodium (Na(V)) channels Na(V)1.1, Na(V)1.2, and Na(V)1.6 are associated with a variety of human diseases including epilepsy, autism spectrum disorder, familial migraine, and other neurodevelopmental disorders. A major obstacle hinde...

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Detalles Bibliográficos
Autores principales: DeKeyser, Jean-Marc, Thompson, Christopher H., George, Alfred L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948969/
https://www.ncbi.nlm.nih.gov/pubmed/33460646
http://dx.doi.org/10.1016/j.jbc.2021.100298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948969/
https://www.ncbi.nlm.nih.gov/pubmed/33460646
http://dx.doi.org/10.1016/j.jbc.2021.100298

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