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Fc γ receptor compositional heterogeneity: Considerations for immunotherapy development
The antibody-binding crystallizable fragment (Fc) γ receptors (FcγRs) are expressed by leukocytes and activate or suppress a cellular response once engaged with an antibody-coated target. Therapeutic mAbs that require FcγR binding for therapeutic efficacy are now frontline treatments for multiple di...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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American Society for Biochemistry and Molecular Biology
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948983/ https://www.ncbi.nlm.nih.gov/pubmed/33172893 http://dx.doi.org/10.1074/jbc.REV120.013168 |