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Fc γ receptor compositional heterogeneity: Considerations for immunotherapy development

The antibody-binding crystallizable fragment (Fc) γ receptors (FcγRs) are expressed by leukocytes and activate or suppress a cellular response once engaged with an antibody-coated target. Therapeutic mAbs that require FcγR binding for therapeutic efficacy are now frontline treatments for multiple di...

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Detalles Bibliográficos
Autor principal:	Barb, Adam W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	JBC Reviews
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948983/ https://www.ncbi.nlm.nih.gov/pubmed/33172893 http://dx.doi.org/10.1074/jbc.REV120.013168

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