Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons

The human genome contains vast genetic diversity as naturally occurring coding variants, yet the impact of these variants on protein function and physiology is poorly understood. RGS14 is a multifunctional signaling protein that suppresses synaptic plasticity in dendritic spines of hippocampal neuro...

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Detalles Bibliográficos
Autores principales: Squires, Katherine E., Gerber, Kyle J., Tillman, Matthew C., Lustberg, Daniel J., Montañez-Miranda, Carolina, Zhao, Meilan, Ramineni, Suneela, Scharer, Christopher D., Saha, Ramendra N., Shu, Feng-Jue, Schroeder, Jason P., Ortlund, Eric A., Weinshenker, David, Dudek, Serena M., Hepler, John R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949046/
https://www.ncbi.nlm.nih.gov/pubmed/33410399
http://dx.doi.org/10.1074/jbc.RA120.016009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949046/
https://www.ncbi.nlm.nih.gov/pubmed/33410399
http://dx.doi.org/10.1074/jbc.RA120.016009

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