Affinity maturation of the RLIP76 Ral binding domain to inform the design of stapled peptides targeting the Ral GTPases

Ral GTPases have been implicated as critical drivers of cell growth and metastasis in numerous Ras-driven cancers. We have previously reported stapled peptides, based on the Ral effector RLIP76, that can disrupt Ral signaling. Stapled peptides are short peptides that are locked into their bioactive...

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Detalles Bibliográficos
Autores principales: Hurd, Catherine A., Brear, Paul, Revell, Jefferson, Ross, Sarah, Mott, Helen R., Owen, Darerca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949049/
https://www.ncbi.nlm.nih.gov/pubmed/33214225
http://dx.doi.org/10.1074/jbc.RA120.015735

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949049/
https://www.ncbi.nlm.nih.gov/pubmed/33214225
http://dx.doi.org/10.1074/jbc.RA120.015735

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