ABHD5 suppresses cancer cell anabolism through lipolysis-dependent activation of the AMPK/mTORC1 pathway

ABHD5 is an essential coactivator of ATGL, the rate-limiting triglyceride (TG) lipase in many cell types. Importantly, ABHD5 also functions as a tumor suppressor, and ABHD5 mRNA expression levels correlate with patient survival for several cancers. Nevertheless, the mechanisms involved in ABHD5-depe...

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Detalles Bibliográficos
Autores principales: Chen, Guohua, Zhou, Guoli, Lotvola, Aaron, Granneman, James G., Wang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949079/
https://www.ncbi.nlm.nih.gov/pubmed/33219129
http://dx.doi.org/10.1074/jbc.RA120.014682

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949079/
https://www.ncbi.nlm.nih.gov/pubmed/33219129
http://dx.doi.org/10.1074/jbc.RA120.014682

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