mTOR kinase inhibition disrupts neuregulin 1-ERBB3 autocrine signaling and sensitizes NF2-deficient meningioma cellular models to IGF1R inhibition

Meningiomas (MNs), arising from the arachnoid/meningeal layer, are nonresponsive to chemotherapies, with ∼50% showing loss of the Neurofibromatosis 2 (NF2) tumor suppressor gene. Previously, we established NF2 loss activates mechanistic target of rapamycin complex 1 (mTORC1) and mechanistic target o...

Descripción completa

Detalles Bibliográficos
Autores principales: Beauchamp, Roberta L., Erdin, Serkan, Witt, Luke, Jordan, Justin T., Plotkin, Scott R., Gusella, James F., Ramesh, Vijaya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949095/
https://www.ncbi.nlm.nih.gov/pubmed/33273014
http://dx.doi.org/10.1074/jbc.RA120.014960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949095/
https://www.ncbi.nlm.nih.gov/pubmed/33273014
http://dx.doi.org/10.1074/jbc.RA120.014960

Ejemplares similares