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O-linked N-acetylglucosamine transferase (OGT) regulates pancreatic α-cell function in mice

The nutrient sensor O-GlcNAc transferase (OGT) catalyzes posttranslational addition of O-GlcNAc onto target proteins, influencing signaling pathways in response to cellular nutrient levels. OGT is highly expressed in pancreatic glucagon-secreting cells (α-cells), which secrete glucagon in response t...

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Detalles Bibliográficos
Autores principales: Essawy, Ahmad, Jo, Seokwon, Beetch, Megan, Lockridge, Amber, Gustafson, Eric, Alejandro, Emilyn U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949098/
https://www.ncbi.nlm.nih.gov/pubmed/33460647
http://dx.doi.org/10.1016/j.jbc.2021.100297