Linker residues regulate the activity and stability of hexokinase 2, a promising anticancer target

Hexokinase (HK) catalyzes the first step in glucose metabolism, making it an exciting target for the inhibition of tumor initiation and progression due to their elevated glucose metabolism. The upregulation of hexokinase-2 (HK2) in many cancers and its limited expression in normal tissues make it a...

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Detalles Bibliográficos
Autores principales: Ferreira, Juliana C., Khrbtli, Abdul-Rahman, Shetler, Cameron L., Mansoor, Samman, Ali, Liaqat, Sensoy, Ozge, Rabeh, Wael M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949118/
https://www.ncbi.nlm.nih.gov/pubmed/33187984
http://dx.doi.org/10.1074/jbc.RA120.015293

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949118/
https://www.ncbi.nlm.nih.gov/pubmed/33187984
http://dx.doi.org/10.1074/jbc.RA120.015293

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