Cargando…

Ceramide synthase 2 deletion decreases the infectivity of HIV-1

The lipid composition of HIV-1 virions is enriched in sphingomyelin (SM), but the roles that SM or other sphingolipids (SLs) might play in the HIV-1 replication pathway have not been elucidated. In human cells, SL levels are regulated by ceramide synthase (CerS) enzymes that produce ceramides, which...

Descripción completa

Detalles Bibliográficos
Autores principales:	Barklis, Eric, Alfadhli, Ayna, Kyle, Jennifer E., Bramer, Lisa M., Bloodsworth, Kent J., Barklis, Robin Lid, Leier, Hans C., Petty, R. Max, Zelnik, Iris D., Metz, Thomas O., Futerman, Anthony H., Tafesse, Fikadu G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7949126/ https://www.ncbi.nlm.nih.gov/pubmed/33515546 http://dx.doi.org/10.1016/j.jbc.2021.100340

Ejemplares similares

The roles of lipids and nucleic acids in HIV-1 assembly
por: Alfadhli, Ayna, et al.
Publicado: (2014)

A potent alpaca-derived nanobody that neutralizes SARS-CoV-2 variants
por: Weinstein, Jules B., et al.
Publicado: (2022)

A global lipid map defines a network essential for Zika virus replication
por: Leier, Hans C., et al.
Publicado: (2020)

Silencing of ceramide synthase 2 in hepatocytes modulates plasma ceramide biomarkers predictive of cardiovascular death
por: Schmidt, Steffen, et al.
Publicado: (2022)

Computational design and molecular dynamics simulations suggest the mode of substrate binding in ceramide synthases
por: Zelnik, Iris D., et al.
Publicado: (2023)

Oxidized Phospholipids Induce Ceramide Accumulation in RAW 264.7 Macrophages: Role of Ceramide Synthases
por: Halasiddappa, Lingaraju M., et al.
Publicado: (2013)

Ceramide phosphoethanolamine synthase SMSr is a target of caspase-6 during apoptotic cell death
por: Cabukusta, Birol, et al.
Publicado: (2017)

Fatty acid transport protein 2 interacts with ceramide synthase 2 to promote ceramide synthesis
por: Kim, Jiyoon L., et al.
Publicado: (2022)

Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER
por: Vacaru, Ana M., et al.
Publicado: (2009)

Ceramide Synthases Expression and Role of Ceramide Synthase-2 in the Lung: Insight from Human Lung Cells and Mouse Models
por: Petrache, Irina, et al.
Publicado: (2013)

Generation of a ceramide synthase 6 mouse lacking the DDRSDIE C-terminal motif
por: Kim, Jiyoon, et al.
Publicado: (2022)

A global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants
por: Farley, Scotland E., et al.
Publicado: (2022)

A novel C-terminal DxRSDxE motif in ceramide synthases involved in dimer formation
por: Kim, Jiyoon L., et al.
Publicado: (2021)

Lipids and pathogenic flaviviruses: An intimate union
por: Leier, Hans C., et al.
Publicado: (2018)

Yeast ceramide synthases, Lag1 and Lac1, have distinct substrate specificity
por: Megyeri, Márton, et al.
Publicado: (2019)

Reduced ceramide synthase 2 activity causes progressive myoclonic epilepsy
por: Mosbech, Mai-Britt, et al.
Publicado: (2014)

The Complex Tail of Circulating Sphingolipids in Atherosclerosis and Cardiovascular Disease
por: Zelnik, Iris D., et al.
Publicado: (2021)

Horse-Derived Ceramide Accentuates Glucosylceramide Synthase and Ceramide Synthase 3 by Activating PPARβ/δ and/or PPARγ to Stimulate Ceramide Synthesis
por: Igarashi, Tami, et al.
Publicado: (2023)

ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6 specific nanobody restricts M. tuberculosis growth in macrophages
por: Bates, Timothy A, et al.
Publicado: (2023)

Hepatic triglyceride accumulation via endoplasmic reticulum stress-induced SREBP-1 activation is regulated by ceramide synthases
por: Kim, Ye-Ryung, et al.
Publicado: (2019)

Mutations affecting cleavage at the p10-capsid protease cleavage site block Rous sarcoma virus replication
por: Vana, Marcy L, et al.
Publicado: (2005)

The Role of Ceramide Synthases in the Pathogenicity of Cryptococcus neoformans
por: Munshi, Mansa A., et al.
Publicado: (2018)

Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer
por: Lee, Wing-Kee, et al.
Publicado: (2021)

A tissue‐specific screen of ceramide expression in aged mice identifies ceramide synthase‐1 and ceramide synthase‐5 as potential regulators of fiber size and strength in skeletal muscle
por: Tosetti, Bettina, et al.
Publicado: (2019)

Ceramides bind VDAC2 to trigger mitochondrial apoptosis
por: Dadsena, Shashank, et al.
Publicado: (2019)

Simulated Night-Shift Schedule Disrupts the Plasma Lipidome and Reveals Early Markers of Cardiovascular Disease Risk
por: Kyle, Jennifer E, et al.
Publicado: (2022)

Ablation of ceramide synthase 2 exacerbates dextran sodium sulphate‐induced colitis in mice due to increased intestinal permeability
por: Kim, Ye‐Ryung, et al.
Publicado: (2017)

Ceramide Synthase 6: Comparative Analysis, Phylogeny and Evolution
por: Holmes, Roger S., et al.
Publicado: (2018)

Overexpression of ceramide synthase 1 increases C18-ceramide and leads to lethal autophagy in human glioma
por: Wang, Zheng, et al.
Publicado: (2017)

Ceramide compensation by ceramide synthases preserves retinal function and structure in a retinal dystrophy mouse model
por: Qian, Xinye, et al.
Publicado: (2023)

Cross-reactivity of SARS-CoV structural protein antibodies against SARS-CoV-2
por: Bates, Timothy A., et al.
Publicado: (2021)

Ceramide Synthase 2 Null Mice Are Protected from Ovalbumin-Induced Asthma with Higher T Cell Receptor Signal Strength in CD4+ T Cells
por: Shin, Sun-Hye, et al.
Publicado: (2021)

Cross-reactivity of SARS-CoV structural protein antibodies against SARS-CoV-2
por: Bates, Timothy A., et al.
Publicado: (2020)

Lipidomics Suggests a New Role for Ceramide Synthase in Phagocytosis
por: Pathak, Divya, et al.
Publicado: (2018)

Ceramide Synthases Are Attractive Drug Targets for Treating Metabolic Diseases
por: Raichur, Suryaprakash
Publicado: (2020)

Ceramides promote apoptosis for virus-infected lymphoma cells through induction of ceramide synthases and viral lytic gene expression
por: Dai, Lu, et al.
Publicado: (2015)

Ceramide Synthase 6 Deficiency Enhances Inflammation in the DSS model of Colitis
por: Helke, Kristi, et al.
Publicado: (2018)

Ceramide synthase 4 overexpression exerts oncogenic properties in breast cancer
por: Kim, Su-Jeong, et al.
Publicado: (2023)

Control of Glucosylceramide Production and Morphogenesis by the Bar1 Ceramide Synthase in Fusarium graminearum
por: Rittenour, William R., et al.
Publicado: (2011)

Adoptive Transfer of Ceramide Synthase 6 Deficient Splenocytes Reduces the Development of Colitis
por: Scheffel, Matthew J., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_n3ep3qfknonuhm94n0l3pvpfu7